G. Kirtschig, M. Kinberger, A. Kreuter, R. Simpson, A. Günthert, C. van Hees, K. Becker, M. J. Ramakers, M. Corazza, S. Müller, S. von Seitzberg, M. J. Boffa, R. Stein, G. Barbagli, C. C. Chi, J. N. Dauendorffer, B. Fischer, M. Gaskins, E. Hiltunen-Back, A. Höfinger, N. H. Köllmann, H. Kühn, H. K. Larsen, M. Lazzeri, W. Mendling, A. F. Nikkels, M. Promm, K. K. Rall, S. Regauer, M. Sárdy, N. Sepp, T. Thune, A. Tsiogka, S. Vassileva, L. Voswinkel, L. Wölber, R. N. Werner
JEADV Volume 38, Issue 10, October 2024, Pages 1850-1873
Abstract
Introduction
Lichen sclerosus (LS) is an inflammatory skin disease affecting all ages. LS typically involves the anogenital site where it causes itching and soreness. It may lead to sexual and urinary dysfunction in females and males; however, it may be asymptomatic. First signs of LS are redness and oedema, typically followed by whitening of the genital skin; sometimes fissuring, scarring, shrinkage and fusion of structures may follow in its course. LS is associated with an increased risk of genital cancer. LS has a huge impact on the quality of life of affected patients, and it is important to raise more awareness of this not uncommon disease in order to diagnose and treat it early.
Objectives
The guideline intends to provide guidance on the diagnostic of LS, highlight important aspects in the care of LS patients (part 1), generate recommendations and treatment algorithms (part 2) on topical, interventional and surgical therapy, based on the latest evidence, provide guidance in the management of LS patients during pregnancy, provide guidance for the follow-up of patients with LS and inform about new developments and potential research aspects.


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